Brand  (β version)

PDB ID: 4B6L

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Ligands
Code Name Style Show Link
9ZP 4-[[(4r)-5-cyclopentyl-4-ethyl-3a,4-dihydro-3h-[1,2,4]triazolo[4,3-f]pteridin-7-yl]amino]-N-cyclopropyl-3-methoxy-benzamide PoSSuM
SO4 Sulfate ion PoSSuM
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Structure summary

Code : 4B6L   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Discovery of Oral Polo-Like Kinase (PLK) Inhibitors with Enhanced Selectivity Profile using Residue Targeted Drug Design
Release Data : 2013-08-21
Compound :
mol_id molecule chains synonym
1 SERINE/THREONINE-PROTEIN KINASE PLK3 A POLO-LIKE KINASE 3, CYTOKINE-INDUCIBLE SERINE/THREONINE-PROTEIN KINASE, FGF-INDUCIBLE KINASE, POLO-LIKE KINASE 3, PLK-3, PROLIFERATION-RELATED KINASE
ec: 2.7.11.21
fragment: CATALYTIC KINASE DOMAIN, RESIDUES 52-332
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_vector_type: BACULOVIRUS
expression_system_vector: PBEV10TOPO
Authors : Brown, K., Charrier, J.D., Durrant, S., Griffiths, M., Hudson, C., Kay, D., Knegtel, R., ODonnell, M., Pierard, F., Twin, H., Weber, P., Young, S.
Keywords : TRANSFERASE, KINASE INHIBITORS, WATER-MEDIATED H-BOND
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Discovery of Oral Polo-Like Kinase (Plk) Inhibitors with Enhanced Selectivity Profile Using Residue Targeted Drug Design

Brown, K.,Charrier, J.D.,Durrant, S.  et al.
To be Published 

Reaction

Chain : A
UniProt : Q9H4B4 (PLK3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.21 -
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.21 -
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