Brand  (β version)

PDB ID: 4B4W

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Ligands
Code Name Style Show Link
9L9 (2s)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1h-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid PoSSuM
CL Chloride ion PoSSuM
GOL Glycerol PoSSuM
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 4B4W   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of Acinetobacter baumannii N5, N10- methylenetetrahydrofolate dehydrogenase-cyclohydrolase (FolD) complexed with NADP cofactor and an inhibitor
Release Data : 2012-08-22
Compound :
mol_id molecule chains synonym
1 BIFUNCTIONAL PROTEIN FOLD A,B N5, N10-METHYLENETETRAHYDROFOLATE DEHYDROGENASE-CYCLOHYDROLASE
ec: 1.5.1.5, 3.5.4.9
Source :
mol_id organism_scientific expression_system
1 ACINETOBACTER BAUMANNII ATCC 19606  (taxid:575584) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
Authors : Eadsforth, T.C., Maluf, F.V., Hunter, W.N.
Keywords : OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Acinetobacter Baumannii Fold Ligand Complexes; Potent Inhibitors of Folate Metabolism and a Re-Evaluation of the Ly374571 Structure.

Eadsforth, T.C.,Maluf, F.V.,Hunter, W.N.
(2012)  FEBS J.  279 : 4350

PubMed: 23050773
DOI: 10.1111/FEBS.12025

Reaction

Chain : A, B
UniProt : D0CBC8 (D0CBC8_ACIB2)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10- formyltetrahydrofolate + H(+) 3.5.4.9 HAMAP- Rule:MF_01576
-
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)- 5,10-methenyltetrahydrofolate + NADPH 1.5.1.5 HAMAP- Rule:MF_01576
-