Brand  (β version)

PDB ID: 4B4M

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Ligands
Code Name Style Show Link
JWT N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-fluoro-N-methylbenzenesulfonamide PoSSuM
CL Chloride ion PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 4B4M   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor
Release Data : 2012-10-31
Compound :
mol_id molecule chains
1 GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE A,B,C,D
ec: 2.7.7.74
Source :
mol_id organism_scientific expression_system
1 PSEUDOMONAS AERUGINOSA  (taxid:208964) ESCHERICHIA COLI  (taxid:511693)
strain: PAO1
expression_system_strain: BL21
expression_system_vector_type: PLASMID
expression_system_plasmid: PET23A MODIFIED
Authors : Alphey, M.S., Pirrie, L., Torrie, L.S., Gardiner, M., Westwood, N.J., Gray, D., Naismith, J.H.
Keywords : TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.350 Å )
Citation :

Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.

Alphey, M.S.,Pirrie, L.,Torrie, L.S.  et al.
(2013)  ACS Chem. Biol.  8 : 387 - 396

PubMed: 23138692
DOI: 10.1021/cb300426u

Reaction

Chain : A, B, C, D
UniProt : Q9HU22 (Q9HU22_PSEAE)
Reaction: EC: Evidence:
Physiological Direction:
alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose 2.7.7.24 ARBA:ARBA00001095, RuleBase:RU003706
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