Het-PDB Navi2 (PDB: 4AXB)

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Ligands
Code	Name	Link
CL	Chloride ion	PoSSuM
FP1	N-hydroxy-1-(1-methylpyridin-2(1h)-ylidene)methanamine	PoSSuM
GOL	Glycerol	PoSSuM
K	Potassium ion	PoSSuM
SO4	Sulfate ion	PoSSuM

Non-standard Residues
Code	Name	Show
SBG	O-[(S)-hydroxy(methyl)phosphoryl]-L-serine

Glycosylation
Code	Name	Emphasize
FUL	Beta-L-fucopyranose
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 4AXB

Code :

4AXB PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of soman-aged human butyrylcholinesterase in complex with 2-PAM

Release Data :

2012-08-29

Compound :

mol_id	molecule	chains	synonym
1	CHOLINESTERASE	A	ACYLCHOLINE ACYLHYDROLASE, BUTYRYLCHOLINE ESTERASE, CHOLINE ESTERASE II, PSEUDOCHOLINESTERASE
	ec: 3.1.1.8 fragment: RESIDUES 31-557

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	CRICETULUS GRISEUS (taxid:10029)
	expression_system_common: CHINESE HAMSTER expression_system_cell_line: CHO K1 expression_system_vector_type: PLASMID expression_system_plasmid: PGS

Authors :

Wandhammer, M., de Koning, M., Noort, D., Goeldner, M., Nachon, F.

Keywords :

HYDROLASE, AGING

Exp. method :

X-RAY DIFFRACTION ( 2.40 Å )

Citation :

A Step Toward the Reactivation of Aged Cholinesterases -Crystal Structure of Ligands Binding to Aged Human Butyrylcholinesterase

Wandhammer, M.,De Koning, M.,Van Grol, M. et al.
(2013) Chem.Biol.Interact 203 : 19

Chain :

UniProt :

P06276 (CHLE_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
an acylcholine + H2O = a carboxylate + choline + H(+)	3.1.1.8	PubMed:19368529, PubMed:19452557
an acylcholine + H2O = a carboxylate + choline + H(+)	-	PubMed:19368529, PubMed:19452557

PDB ID: 4AXB