Het-PDB Navi2 (PDB: 4AWO)

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Ligands
Code	Name		Style	Show	Link
99B	5-[(2r)-butan-2-ylamino]-N-{(3-endo)-8-[5-(cyclopropylcarbonyl)pyridin-2-yl]-8-azabicyclo[3.2.1]oct-3-yl}-2-methylbenzene-1,4-dicarboxamide				PoSSuM

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Download interaction data: 4AWO

Code :

4AWO PDBj RCSB PDB PDBe

Header :

CHAPERONE

Title :

Complex of HSP90 ATPase domain with tropane derived inhibitors

Release Data :

2012-08-29

Compound :

mol_id	molecule	chains	synonym
1	HEAT SHOCK PROTEIN HSP 90-ALPHA	A,B	HSP90, HEAT SHOCK 86 KDA, HSP 86, HSP86, RENAL CARCINOMA ANTIGEN NY-REN-38
	ec: 3.6.4.10 fragment: ATPASE DOMAIN, RESIDUES 9-236

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:562)

Authors :

Lougheed, J.C., Stout, T.J.

Keywords :

CHAPERONE

Exp. method :

X-RAY DIFFRACTION ( 1.70 Å )

Citation :

Discovery of Xl888: A Novel Tropane-Derived Small Molecule Inhibitor of Hsp90.

Bussenius, J.,Blazey, C.M.,Aay, N. et al.
(2012) Bioorg.Med.Chem.Lett. 22 : 5396

Chain :

A, B

UniProt :

P07900 (HS90A_HUMAN)

PDB ID: 4AWO