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Ligands
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CI1 (2z)-4-[(3s)-1-(benzylsulfonyl)-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid
MN Manganese (II) ion
Non-standard Residues
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Code : 4AWK   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1
Release Data : 2012-08-29
Compound :
mol_id molecule chains
1 POLYMERASE PA A
fragment: ENDONUCLEASE, RESIDUES 1-198
Source :
mol_id organism_scientific expression_system
1 INFLUENZA A VIRUS  (taxid:641501) ESCHERICHIA COLI  (taxid:469008)
strain: A/CALIFORNIA/04/2009(H1N1)
expression_system_strain: BL21(DE3)
other_details: SYNTHETIC GENE
Authors : Kowalinski, E., Zubieta, C., Wolkerstorfer, A., Szolar, O.H., Ruigrok, R.W., Cusack, S.
Keywords : HYDROLASE, MANGANESE-DEPENDENT, PD...D-E...K SUPERFAMILY
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.

Kowalinski, E.,Zubieta, C.,Wolkerstorfer, A.  et al.
(2012)  Plos Pathog.  8 : 2831

PubMed: 22876177
DOI: 10.1371/JOURNAL.PPAT.1002831

Chain : A
UniProt : C3W5S0 (C3W5S0_I09A0)
Reaction : -