Brand  (β version)

PDB ID: 4AJF

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Ligands
Code Name Style Show Link
F03 N-(4-oxo-3h-quinazolin-2-yl)acetamide PoSSuM
MG Magnesium ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4AJF   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Identification and structural characterization of PDE10 fragment inhibitors
Release Data : 2013-03-06
Compound :
mol_id molecule chains synonym
1 CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A A,D PDE10, PHOSPHODIESTERASE 10A
ec: 3.1.4.17, 3.1.4.35
fragment: CATALYTIC DOMAIN, RESIDUES 439-764
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
Authors : Johansson, P., Albert, J.S., Spadola, L., Akerud, T., Back, E., Hillertz, P., Horsefeld, R., Scott, C., Spear, N., Tian, G., Tigerstrom, A., Aharony, D., Geschwindner, S.
Keywords : HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Identification and Structural Characterization of Pde10 Fragment Inhibitors

Johansson, P.,Albert, J.S.,Spadola, L.  et al.
To be Published 

Reaction

Chain : A, D
UniProt : Q9Y233 (PDE10_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'- phosphate + H(+) 3.1.4.17 PubMed:10373451, PubMed:10393245, PubMed:17389385, PubMed:27058447
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3',5'-cyclic AMP + H2O = AMP + H(+) - PubMed:10373451, PubMed:10393245, PubMed:16330539, PubMed:17389385, PubMed:27058447
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3',5'-cyclic GMP + H2O = GMP + H(+) - PubMed:10373451, PubMed:10393245, PubMed:17389385, PubMed:27058447
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