Brand  (β version)

PDB ID: 4A93

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
BRU 5-bromo-2'-deoxyuridine-5'-monophosphate
TT [(1r,3r,4s,9r,10s,12r,15as,15br,18br,18cs)-10-hydroxy-15a,15b-dimethyl-13,15,16,18-tetraoxohexadecahydro-8h-9,12-epoxy-1,4-methano-2,5,7-trioxa-12a,14,17,18a-tetraazacyclohexadeca[1,2,3,4-def]biphenylen-3-yl]methyl dihydrogen phosphate
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4A93   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : RNA Polymerase II elongation complex containing a CPD Lesion
Release Data : 2012-03-21
Compound :
mol_id molecule chains synonym
1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 A RPB1, RNA POLYMERASE II SUBUNIT 1, RNA POLYMERASE II SUBUNIT B1, DNA-DIRECTED RNA POLYMERASE III LARGEST SUBUNIT, RNA POLYMERASE II SUBUNIT B220
ec: 2.7.7.6
fragment: RESIDUES 1-1732
mol_id molecule chains synonym
2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 B RPB2, RNA POLYMERASE II SUBUNIT 2, B150, DNA-DIRECTED RNA POLYMERASE II 140 KDA POLYPEPTIDE
ec: 2.7.7.6
mol_id molecule chains synonym
3 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 C RPB3, RNA POLYMERASE II SUBUNIT 3, RNA POLYMERASE II SUBUNIT B3, B44.5, DNA-DIRECTED RNA POLYMERASE II 45 KDA POLYPEPTIDE
mol_id molecule chains synonym
4 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4 D RPB4, RNA POLYMERASE II SUBUNIT B4, B32, DNA-DIRECTED RNA POLYMERASE II 32 KDA POLYPEPTIDE
mol_id molecule chains synonym
5 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 E RPB5, RNA POLYMERASES I\,II\,AND III SUBUNIT ABC1, ABC27, DNA-DIRECTED RNA POLYMERASES I\,II\,AND III 27 KDA POLYPEPTIDE
mol_id molecule chains synonym
6 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 F RPB6, RNA POLYMERASES I\,II\,AND III SUBUNIT ABC2, ABC23, DNA-DIRECTED RNA POLYMERASES I\,II\,AND III 23 KDA POLYPEPTIDE
mol_id molecule chains synonym
7 RPB7, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 G RNA POLYMERASE II SUBUNIT B7, B16
mol_id molecule chains synonym
8 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 H RPB8, RNA POLYMERASES I\,II\,AND III SUBUNIT ABC3, ABC14.4, ABC14.5, DNA-DIRECTED RNA POLYMERASES I\,II\,AND III 14.5 KDA POLYPEPTIDE
mol_id molecule chains synonym
9 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9 I RBP9, RNA POLYMERASE II SUBUNIT B9, B12.6, DNA-DIRECTED RNA POLYMERASE II 14.2 KDA POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II SUBUNIT 9
mol_id molecule chains synonym
10 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 J RPB10, RNA POLYMERASES I\,II\,AND III SUBUNIT ABC5, ABC10-BETA, ABC8, DNA-DIRECTED RNA POLYMERASES I\,II\,AND III 8.3 KDA POLYPEPTIDE
mol_id molecule chains synonym
11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 K RPB11, RNA POLYMERASE II SUBUNIT B11, B13.6, DNA-DIRECTED RNA POLYMERASE II 13.6 KDA POLYPEPTIDE
mol_id molecule chains synonym
12 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 L RPB12, RNA POLYMERASES I\,II\,AND III SUBUNIT ABC4, ABC10-ALPHA
mol_id molecule chains synonym
13 5'-D(*TP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*TP)-3' N NON TEMPLATE DNA
mol_id molecule chains synonym
14 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*GP*AP*AP)-3' P TRANSCRIPT RNA
mol_id molecule chains synonym
15 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP*CP*T*TTP*TP*TP*CP*C BRUP*GP*GP*TP*CP*AP*TP*T)-3' T TEMPLATE DNA
Source :
mol_id organism_scientific organism_common
1 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
mol_id organism_scientific organism_common
2 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
mol_id organism_scientific organism_common
3 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
mol_id organism_scientific organism_common
4 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
mol_id organism_scientific organism_common
5 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
mol_id organism_scientific organism_common
6 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
mol_id organism_scientific organism_common
7 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
mol_id organism_scientific organism_common
8 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
mol_id organism_scientific organism_common
9 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
mol_id organism_scientific organism_common
10 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
mol_id organism_scientific organism_common
11 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
mol_id organism_scientific organism_common
12 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
mol_id organism_scientific organism_common
13 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
synthetic: yes
mol_id organism_scientific organism_common
14 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
synthetic: yes
mol_id organism_scientific organism_common
15 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
synthetic: yes
Authors : Walmacq, C., Cheung, A.C.M., Kireeva, M.L., Lubkowska, L., Ye, C., Gotte, D., Strathern, J.N., Carell, T., Cramer, P., Kashlev, M.
Keywords : TRANSCRIPTION, TRANSCRIPTION FIDELITY, TRANSCRIPTION COUPLED DNA REPAIR, DNA DAMAGE, DNA REPAIR, PYRIMIDINE DIMERS
Exp. method : X-RAY DIFFRACTION ( 3.400 Å )
Citation :

Mechanism of Translesion Transcription by RNA Polymerase II and its Role in Cellular Resistance to DNA Damage.

Walmacq, C.,Cheung, A.C.,Kireeva, M.L.  et al.
(2012)  Mol.Cell  46 : 18

PubMed: 22405652
DOI: 10.1016/J.MOLCEL.2012.02.006

Reaction

Chain : A
UniProt : P04050 (RPB1_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.6 -
-
Chain : B
UniProt : P08518 (RPB2_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.6 -
-
Chain : C
UniProt : P16370 (RPB3_YEAST)
Reaction : -
Chain : D
UniProt : P20433 (RPB4_YEAST)
Reaction : -
Chain : E
UniProt : P20434 (RPAB1_YEAST)
Reaction : -
Chain : F
UniProt : P20435 (RPAB2_YEAST)
Reaction : -
Chain : G
UniProt : P34087 (RPB7_YEAST)
Reaction : -
Chain : H
UniProt : P20436 (RPAB3_YEAST)
Reaction : -
Chain : I
UniProt : P27999 (RPB9_YEAST)
Reaction : -
Chain : J
UniProt : P22139 (RPAB5_YEAST)
Reaction : -
Chain : K
UniProt : P38902 (RPB11_YEAST)
Reaction : -
Chain : L
UniProt : P40422 (RPAB4_YEAST)
Reaction : -