Brand  (β version)

PDB ID: 452D

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Ligands
Code Name Style Show Link
9AD 9-amino-(N-(2-dimethylamino)ethyl)acridine-4-carboxamide PoSSuM
MPD (4s)-2-methyl-2,4-pentanediol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 452D   PDBj   RCSB PDB   PDBe
Header : DNA
Title : ACRIDINE BINDING TO DNA
Release Data : 2003-03-04
Compound :
mol_id molecule chains
1 DNA (5'-D(*CP*GP*TP*AP*CP*G)-3') A
Source :
mol_id organism_scientific
1
synthetic: yes
Authors : Thorpe, J.H., Todd, A.K., Cardin, C.J.
Keywords : INTERCALATION, GROOVE BINDING, DNA
Exp. method : X-RAY DIFFRACTION ( 1.6 Å )
Citation :

Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethlyamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5Br-U)ACG)2 at 1.3-angstrom resolution

Todd, A.K.,Adams, A.,Thorpe, J.H.  et al.
(1999)  J.Med.Chem.  42 : 536 - 540

PubMed: 10052960
DOI: 10.1021/jm980479u