Brand  (β version)

PDB ID: 3ZH8

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Ligands
Code Name Style Show Link
IOD Iodide ion PoSSuM
CL Chloride ion PoSSuM
C58 (2s)-3-phenyl-N~1~-[2-(pyridin-4-yl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4-yl]propane-1,2-diamine PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
Code Name Show
TPO Phosphothreonine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3ZH8   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : A novel small molecule aPKC inhibitor
Release Data : 2013-02-27
Compound :
mol_id molecule chains synonym
1 PROTEIN KINASE C IOTA TYPE A,B,C PKC IOTA, ATYPICAL PROTEIN KINASE C-LAMBDA/IOTA, PRKC-LAMBDA/IOTA, APKC-LAMBDA/IOTA, NPKC-IOTA
ec: 2.7.11.13
fragment: KINASE DOMAIN, RESIDUES 248-596
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_cell_line: High Five
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PBACPAK-HIS3
Authors : Kjaer, S., Purkiss, A.G., Kostelecky, B., Knowles, P.P., Soriano, E., Murray-Rust, J., McDonald, N.Q.
Keywords : TRANSFERASE, AGC KINASES, CELL POLARITY, CELL MIGRATION
Exp. method : X-RAY DIFFRACTION ( 2.739 Å )
Citation :

Adenosine-Binding Motif Mimicry and Cellular Effects of a Thieno[2,3-D]Pyrimidine-Based Chemical Inhibitor of Atypical Protein Kinase C Isozymes.

Kjaer, S.,Linch, M.,Purkiss, A.  et al.
(2013)  Biochem.J.  451 : 329

PubMed: 23418854
DOI: 10.1042/BJ20121871

Reaction

Chain : A, B, C
UniProt : P41743 (KPCI_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.13 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.13 -
-