Brand  (β version)

PDB ID: 3W7F

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Ligands
Code Name Style Show Link
FPS S-[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trienyl] trihydrogen thiodiphosphate PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3W7F   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of the C(30) carotenoid dehydrosqualene synthase from staphylococcus aureus complexed with farnesyl thiopyrophosphate
Release Data : 2013-04-10
Compound :
mol_id molecule chains synonym
1 Dehydrosqualene synthase A,B 4,4'-diapophytoene synthase, DAP synthase, Diapophytoene synthase
ec: 2.5.1.96
Source :
mol_id organism_scientific expression_system
1 Staphylococcus aureus  (taxid:1280) ESCHERICHIA COLI  (taxid:562)
strain: ATCC 27659
gene: crtM
expression_system_strain: BL-21 (DE3) PLYSS
expression_system_vector_type: PLASMID
expression_system_plasmid: PET-32 XA/LIC
Authors : Liu, C.I., Jeng, W.Y., Wang, A.H., Oldfield, E.
Keywords : CrtM, FsPP, Carotenoid biosynthesis, Staphyloxanthin biosynthesis, Transferase, Head-to-head condensation
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.

Liu, C.I.,Liu, G.Y.,Song, Y.  et al.
(2008)  Science  319 : 1391 - 1394

PubMed: 18276850
DOI: 10.1126/science.1153018

Reaction

Chain : A, B
UniProt : A9JQL9 (CRTM_STAAU)
Reaction: EC: Evidence:
Physiological Direction:
2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate 2.5.1.96 PubMed:18276850
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