Het-PDB Navi2 (PDB: 3W2O)

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Ligands
Code	Name		Style	Show	Link
03P	N-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-D]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide				PoSSuM

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Download interaction data: 3W2O

Code :

3W2O PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

EGFR Kinase domain T790M/L858R Mutant with TAK-285

Release Data :

2013-01-16

Compound :

mol_id	molecule	chains	synonym
1	Epidermal growth factor receptor	A	Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
	ec: 2.7.10.1 fragment: Kinase domain, UNP residues 698-1022 mutation: T790M/L858R

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: EGFR, ERBB, ERBB1, HER1 expression_system_cell_line: SF9 expression_system_vector_type: Baculovirus expression_system_plasmid: pFastBac1

Authors :

Sogabe, S., Kawakita, Y., Igaki, S.

Keywords :

ANTI-ONCOGENE, CELL CYCLE, DISEASE MUTATION, KINASE DOMAIN, RECEPTOR, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.35 Å )

Citation :

Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.

Sogabe, S.,Kawakita, Y.,Igaki, S. et al.
(2013) Acs Med.Chem.Lett. 4 : 201 - 205

Chain :

UniProt :

P00533 (EGFR_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:15374980, PubMed:17349580, PubMed:18046415, PubMed:18227510, PubMed:19560417, PubMed:19563760
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PDB ID: 3W2O