Brand  (β version)

PDB ID: 3VRB

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Ligands
Code Name Style Show Link
FUM Fumaric acid PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
SF4 Iron/sulfur cluster PoSSuM
F3S Fe3-s4 cluster PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
FTN N-[3-(1-methylethoxy)phenyl]-2-(trifluoromethyl)benzamide PoSSuM
EPH L-alpha-phosphatidyl-beta-oleoyl-gamma-palmitoyl-phosphatidylethanolamine PoSSuM
Non-standard Residues
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Structure summary

Code : 3VRB   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Title : Mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum with the specific inhibitor flutolanil and substrate fumarate
Release Data : 2012-07-11
Compound :
mol_id molecule chains synonym
1 Flavoprotein subunit of complex II A,E Rhodoquinol-fumarate reductase Fp subunit
mol_id molecule chains synonym
2 Iron-sulfur subunit of succinate dehydrogenase B,F Rhodoquinol-fumarate reductase Ip subunit
mol_id molecule chains synonym
3 Cytochrome b-large subunit C,G Rhodoquinol-fumarate reductase CybL subunit
mol_id molecule chains synonym
4 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial D,H Rhodoquinol-fumarate reductase CybS subunit, CybS, Cytochrome b558 small subunit, Succinate-ubiquinone reductase membrane anchor subunit
Source :
mol_id organism_scientific organism_common
1 Ascaris suum  (taxid:6253) Pig roundworm
organelle: mitochondria
other_details: adult
mol_id organism_scientific organism_common
2 Ascaris suum  (taxid:6253) Pig roundworm
organelle: mitochondria
other_details: adult
mol_id organism_scientific organism_common
3 Ascaris suum  (taxid:6253) Pig roundworm
organelle: mitochondria
other_details: adult
mol_id organism_scientific organism_common
4 Ascaris suum  (taxid:6253) Pig roundworm
organelle: mitochondria
other_details: adult
Authors : Shimizu, H., Shiba, T., Inaoka, D.K., Osanai, A., Kita, K., Sakamoto, K., Harada, S.
Keywords : Ascaris suum, membrane protein, reductase, mitochondrial membrane, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.91 Å )
Citation :

Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum

Shimizu, H.,Osanai, A.,Sakamoto, K.  et al.
(2012)  J.Biochem.  151 : 589 - 592

PubMed: 22577165
DOI: 10.1093/jb/mvs051

Reaction

Chain : A, E
UniProt : Q33862 (SDHA1_ASCSU)
Reaction: EC: Evidence:
Physiological Direction:
a rhodoquinone + succinate = a rhodoquinol + fumarate 1.3.5.1 PubMed:12742584, PubMed:17933581, PubMed:2843227, PubMed:7822332, PubMed:8435436
right-to-left
Cofactor: Evidence: Note:
FAD ECO:0000255 | RuleBase:RU362051
Binds 1 FAD covalently per subunit.
Chain : B, F
UniProt : O44074 (SDHB_ASCSU)
Reaction: EC: Evidence:
Physiological Direction:
a ubiquinone + succinate = a ubiquinol + fumarate 1.3.5.1 PubMed:10743611, PubMed:12742584, PubMed:17933581, PubMed:26198225, PubMed:2843227, PubMed:7822332, PubMed:8435436
left-to-right PubMed:10743611, PubMed:12742584, PubMed:17933581, PubMed:26198225, PubMed:7822332, PubMed:8435436
a rhodoquinone + succinate = a rhodoquinol + fumarate 1.3.5.1 PubMed:10743611, PubMed:12742584, PubMed:17933581, PubMed:2843227, PubMed:7822332, PubMed:8435436
right-to-left
Cofactor: Evidence: Note:
[2Fe-2S] cluster ECO:0000255 | RuleBase:RU361237
Binds 1 [2Fe-2S] cluster.
[3Fe-4S] cluster ECO:0000255 | RuleBase:RU361237
Binds 1 [3Fe-4S] cluster.
[4Fe-4S] cluster ECO:0000255 | RuleBase:RU361237
Binds 1 [4Fe-4S] cluster.
Chain : C, G
UniProt : P92506 (DHSC_ASCSU)
Reaction : -
Cofactor: Evidence: Note:
heme b ECO:0000250 | UniProtKB:D0VWV4
The heme is bound between the two transmembrane subunits CybS and CybL.
Chain : D, H
UniProt : P92507 (DHSD1_ASCSU)
Reaction : -
Cofactor: Evidence: Note:
heme b ECO:0000250 | UniProtKB:D0VWV4
The heme b is bound between the two transmembrane subunits CybS and CybL.