PDB ID: 3VO3
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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0KF | N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-B]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1h-pyrazole-5-carboxamide | PoSSuM | |||
EDO | 1,2-ethanediol | PoSSuM |
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Download interaction data: 3VO3
Structure summary
Code : | 3VO3 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||
Title : | Crystal Structure of the Kinase domain of Human VEGFR2 with imidazo[1,2-B]pyridazine derivative | ||||||||||||
Release Data : | 2013-03-06 | ||||||||||||
Compound : |
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Authors : | Oki, H., Okada, K. | ||||||||||||
Keywords : | vegfr2, kinase domain, Tyrosin-protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.5200 Å ) | ||||||||||||
Citation : |
Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor
Miyamoto, N.,Sakai, N.,Hirayama, T.
et al.
PubMed: 23498918 |
Reaction
Chain : | A | ||||||||
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UniProt : | P35968 (VGFR2_HUMAN) | ||||||||
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