Brand  (β version)

PDB ID: 3VEV

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Ligands
Code Name Style Show Link
0H4 (2s)-3-cyclopentyl-N-(5-methylpyridin-2-yl)-2-[2-oxo-4-(trifluoromethyl)pyridin-1(2h)-yl]propanamide PoSSuM
NA Sodium ion PoSSuM
GLC Alpha-D-glucopyranose PoSSuM
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Structure summary

Code : 3VEV   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE ACTIVATOR
Title : Glucokinase in complex with an activator and glucose
Release Data : 2012-02-08
Compound :
mol_id molecule chains synonym
1 Glucokinase A Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D
ec: 2.7.1.2
fragment: UNP residues 12-465
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: GCK
Authors : Liu, S.
Keywords : catalysis reaction, TRANSFERASE, TRANSFERASE-TRANSFERASE ACTIVATOR complex
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS.

Liu, S.,Ammirati, M.J.,Song, X.  et al.
(2012)  J.Biol.Chem.  287 : 13598 - 13610

PubMed: 22298776
DOI: 10.1074/jbc.M111.274126

Reaction

Chain : A
UniProt : P35557 (HXK4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+) 2.7.1.1 PubMed:11916951, PubMed:15277402, PubMed:17082186, PubMed:18322640, PubMed:19146401, PubMed:25015100, PubMed:8325892
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ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+) 2.7.1.1 PubMed:7742312
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ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+) 2.7.1.1 PubMed:7742312
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ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+) 2.7.1.1 PubMed:7742312
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