PDB ID: 3VEU
Hetero Atom Contents
The number of atoms exceeds 100,000. So, it can not be displayed here.
Select unit:
Select hetatm:
Select chain: Sequence
Data format:
Color scheme of protein:
Code | Name | Style | Show | Link | |
---|---|---|---|---|---|
0GO | (2s)-N-[(2s,3r)-3-hydroxy-1-phenyl-4-{[3-(propan-2-yl)benzyl]amino}butan-2-yl]-2-[(5s)-6-oxo-1-propyl-1,7-diazaspiro[4.4]non-7-yl]propanamide | PoSSuM |
Code | Name | Show |
---|
Code | Name | Emphasize |
---|
Code | Name | Show |
---|
Download interaction data: 3VEU
Structure summary
Code : | 3VEU PDBj RCSB PDB PDBe | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Header : | Hydrolase/Hydrolase inhibitor | ||||||||||||
Title : | Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326 | ||||||||||||
Release Data : | 2012-11-21 | ||||||||||||
Compound : |
|
||||||||||||
Source : |
|
||||||||||||
Authors : | Rondeau, J.M., Bourgier, E. | ||||||||||||
Keywords : | Structure-based drug design, Hydrolase, Hydrolase-Hydrolase inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.5200 Å ) | ||||||||||||
Citation : |
Discovery of cyclic sulfone hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides
Rueeger, H.,Lueoend, R.,Rogel, O.
et al.
PubMed: 22380629 Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors.
Rueeger, H.,Rondeau, J.M.,McCarthy, C.
et al.
PubMed: 21388807 |
Reaction
Chain : | A | ||||||||
---|---|---|---|---|---|---|---|---|---|
UniProt : | P56817 (BACE1_HUMAN) | ||||||||
|