Brand  (β version)

color scheme of protein:


interaction residue:

chain: Hide other chain(s)

Code Name Link
0GV (3beta,8alpha,9beta)-3-hydroxycholest-5-en-7-one
HEM Protoporphyrin ix containing Fe
SO4 Sulfate ion
UNX Unknown atom or ion
Code : 3V8D
Title : Crystal structure of human CYP7A1 in complex with 7-ketocholesterol
Release Data : 2013-01-09
Compound :
mol_id molecule chains synonym
1 Cholesterol 7-alpha-monooxygenase A,B CYPVII, Cholesterol 7-alpha-hydroxylase, Cytochrome P450 7A1
fragment: UNP residues 25-503
mutation: T104L
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CYP7A1, CYP7
expression_system_strain: JM109
expression_system_vector_type: plasmid
expression_system_plasmid: pCW
Authors : Strushkevich, N., Tempel, W., MacKenzie, F., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Usanov, S.A., Park, H., Structural Genomics Consortium (SGC)
Keywords : cytochrome, OXIDOREDUCTASE, Structural Genomics, Structural Genomics Consortium, SGC
Exp. method : X-RAY DIFFRACTION ( 1.9000 Å )
Citation :

Crystal structure of human CYP7A1 in complex with 7-ketocholesterol

Strushkevich, N.,Tempel, W.,MacKenzie, F.  et al.
To be Published 

Chain : A, B
UniProt : P22680 (CP7A1_HUMAN)
Reaction : Cholesterol + [reduced NADPH--hemoprotein reductase] + O(2) = 7-alpha-hydroxycholesterol + [oxidized NADPH-- hemoprotein reductase] + H(2)O.