Het-PDB Navi2 (PDB: 3V7T)

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Ligands
Code	Name		Style	Show	Link
0GX	{(3-exo)-3-[5-(aminomethyl)-2-fluorophenyl]-8-azabicyclo[3.2.1]oct-8-yl}(4-bromo-3-methyl-5-propoxythiophen-2-yl)methanone				PoSSuM
CO3	Carbonate ion				PoSSuM

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Download interaction data: 3V7T

Code :

3V7T PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Crystal Structure of Human Beta-Tryptase Complexed with a Synthetic Inhibitor with a Tropanylamide Scaffold

Release Data :

2012-03-14

Compound :

mol_id	molecule	chains
1	TPSB2 protein	A,B,C,D
	fragment: unp residues 38-282

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Komagataella pastoris (taxid:4922)
	gene: TPSB2 expression_system_common: Pichia pastoris

Authors :

Zhang, Y., Colonna, C., Michot, N.

Keywords :

tryptase, serine protease, tetramer, protein-ligand complex, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.0900 Å )

Citation :

A beta-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity

Liang, G.,Choi-Sledeski, Y.M.,Shum, P. et al.
(2012) Bioorg.Med.Chem.Lett. 22 : 1606 - 1610

PDB ID: 3V7T