Het-PDB Navi2 (PDB: 3V4V)

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Ligands
Code	Name	Link
CA	Calcium ion	PoSSuM
TRS	2-amino-2-hydroxymethyl-propane-1,3-diol	PoSSuM
MG	Magnesium ion	PoSSuM
0DU	N-(2,6-dichlorobenzoyl)-4-[1,6-dimethyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl]-L-phenylalanine	PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose
BMA	Beta-D-mannopyranose
MAN	Alpha-D-mannopyranose

Modification
Code	Name	Show

Download interaction data: 3V4V

Code :

3V4V PDBj RCSB PDB PDBe

Header :

CELL ADHESION

Title :

crystal structure of a4b7 headpiece complexed with Fab ACT-1 and RO0505376

Release Data :

2012-01-11

Compound :

mol_id	molecule	chains	synonym
1	Integrin alpha-4	A,C	CD49 antigen-like family member D, Integrin alpha-IV, VLA-4 subunit alpha
	fragment: unp residues 34-620 mutation: R558A

mol_id	molecule	chains	synonym
2	Integrin beta-7	B,D	Gut homing receptor beta subunit
	fragment: unp residues 20-512

mol_id	molecule	chains
3	MONOCLONAL ANTIBODY Act-1 HEAVY CHAIN	H,M

mol_id	molecule	chains
4	MONOCLONAL ANTIBODY Act-1 LIGHT CHAIN	L,N

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Cricetulus griseus (taxid:10029)
	gene: ITGA4, CD49D expression_system_common: Chinese hamster expression_system_cell_line: CHO

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Cricetulus griseus (taxid:10029)
	gene: ITGB7 expression_system_common: Chinese hamster expression_system_cell_line: CHO

mol_id	organism_scientific	organism_common	expression_system
3	Mus musculus (taxid:10090)	Mouse	Mus musculus (taxid:10090)

mol_id	organism_scientific	organism_common	expression_system
4	Mus musculus (taxid:10090)	Mouse	Mus musculus (taxid:10090)

Authors :

Yu, Y., Zhu, J., Springer, T.A.

Keywords :

Cell Adhesion, MAdCAM-1, Membrane

Exp. method :

X-RAY DIFFRACTION ( 3.100 Å )

Citation :

Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion

Yu, Y.,Zhu, J.,Mi, L.Z. et al.
(2012) J.Cell Biol. 196 : 131 - 146

PDB ID: 3V4V