Brand  (β version)

PDB ID: 3UVQ

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Ligands
Code Name Style Show Link
FS8 N-{5-[(7-{[(2r)-2,3-dihydroxypropyl]oxy}-5-oxo-10,11-dihydro-5h-dibenzo[a,D][7]annulen-2-yl)amino]-2-fluorophenyl}benzamide PoSSuM
BOG Octyl beta-D-glucopyranoside PoSSuM
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Structure summary

Code : 3UVQ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Human p38 MAP Kinase in Complex with a Dibenzosuberone Derivative
Release Data : 2012-12-05
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 14 A MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, SAPK2A
ec: 2.7.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pGEX 6P-1
Authors : Mayer-Wrangowski, S.C., Richters, A., Gruetter, C., Rauh, D.
Keywords : selective p38 inhibitor, SAR, dibenzosuberone derivative, protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.2000 Å )
Citation :

Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.

Fischer, S.,Wentsch, H.K.,Mayer-Wrangowski, S.C.  et al.
(2013)  J.Med.Chem.  56 : 241 - 253

PubMed: 23270382
DOI: 10.1021/jm301539x

Reaction

Chain : A
UniProt : Q16539 (MK14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right PubMed:11010976, PubMed:35857590