PDB ID: 3UUO
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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0CV | 6-methoxy-3,8-dimethyl-4-(piperazin-1-yl)-1h-pyrazolo[3,4-B]quinoline | PoSSuM | |||
MG | Magnesium ion | PoSSuM | |||
ZN | Zinc ion | PoSSuM | |||
PO4 | Phosphate ion | PoSSuM |
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Download interaction data: 3UUO
Structure summary
Code : | 3UUO PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||
Title : | The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as PDE10 inhibitors for the treatment of Schizophrenia | ||||||||||||
Release Data : | 2012-01-25 | ||||||||||||
Compound : |
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Source : |
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Authors : | Ho, G.D., Yang, S., Smotryski, J., Bercovici, A., Nechuta, T., Smith, E.M., McElroy, W., Tan, Z., Tulshian, D., Mckittrick, B., Greenlee, W.J., Hruza, A., Xiao, L., Rindgen, D., Guzzi, M., Zhang, X., Bleickardt, C., Mullins, D., Hodgson, R. | ||||||||||||
Keywords : | INHIBITOR COMPLEX, HYDROLASE, ZN BINDING, MG BINDING, HYDROLASE-HYDROLASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.11 Å ) | ||||||||||||
Citation : |
The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.
Ho, G.D.,Yang, S.W.,Smotryski, J.
et al.
PubMed: 22222034 |
Reaction
Chain : | A, B | ||||||||||||||||
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UniProt : | Q9Y233 (PDE10_HUMAN) | ||||||||||||||||
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