Brand  (β version)

PDB ID: 3UHM

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
GAI Guanidine PoSSuM
RFN (2r)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyridin-1(2h)-yl)butanamide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3UHM   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase inhibitor
Title : UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase in complex with inhibitor
Release Data : 2012-02-01
Compound :
mol_id molecule chains synonym
1 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase A Protein envA, UDP-3-O-acyl-GlcNAc deacetylase
ec: 3.5.1.-
mutation: C40S
Source :
mol_id organism_scientific expression_system
1 Pseudomonas aeruginosa  (taxid:287) Escherichia coli  (taxid:562)
gene: lpxC, envA, PA4406
expression_system_vector_type: plasmid
expression_system_plasmid: PET21B
Authors : Montgomery, J., Liu, S.
Keywords : Amidohydrolases, Anti-Bacterial Agents, Bacteria, Catalytic Domain, Drug Design, Enzyme Inhibitors, Gram Negative, Hydrolase-Hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.26 Å )
Citation :

Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.

Montgomery, J.I.,Brown, M.F.,Reilly, U.  et al.
(2012)  J.Med.Chem.  55 : 1662 - 1670

PubMed: 22257165
DOI: 10.1021/jm2014875

Reaction

Chain : A
UniProt : P47205 (LPXC_PSEAE)
Reaction: EC: Evidence:
Physiological Direction:
a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate 3.5.1.108 HAMAP-Rule:MF_00388, PubMed:9068651
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