Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
09H 2-(2,3-dihydro-1-benzofuran-5-yl)-N-[2-(piperazin-1-yl)phenyl]-1,3-thiazole-4-carboxamide
Code : 3U9N
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : X-ray crystal structure of compound 1 bound to human CHK1 kinase domain
Release Data : 2012-01-25
Compound :
mol_id molecule chains
1 Serine/threonine-protein kinase Chk1 A
ec: 2.7.11.1
fragment: Kinase domain, UPN residues 2-274
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CHEK1, CHK1
expression_system_common: Fall armyworm
expression_system_strain: SF9
expression_system_vector_type: baculovirus
Authors : Fischmann, T.O.
Keywords : Protein kinase domain, ATPase, ATP Binding, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Discovery of a Novel Series of CHK1 Kinase Inhibitors with Distinctive Hinge Binding Mode

Huang, X.,Cheng, C.C.,Fischmann, T.O.  et al.
(2012)  ACS MED.CHEM.LETT. 

Chain : A
UniProt : O14757 (CHK1_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.