Brand  (β version)

PDB ID: 3U8W

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Ligands
Code Name Style Show Link
09J 3-[3-(2-chloro-6-fluorophenyl)-5-ethyl-6-oxo-5,6-dihydro[1,2,4]triazolo[4,3-B]pyridazin-7-yl]-N-cyclopropyl-4-methylbenzamide PoSSuM
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Structure summary

Code : 3U8W   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Triazolopyridazinone inhibitor
Release Data : 2012-08-29
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 14 A MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, SAPK2A
ec: 2.7.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2
Authors : Mohr, C., Jordan, S.
Keywords : Serine/Threonine Protein Kinase, Transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Identification of triazolopyridazinones as potent p38alpha inhibitors.

Herberich, B.,Jackson, C.,Wurz, R.P.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 1226 - 1229

PubMed: 22196117
DOI: 10.1016/j.bmcl.2011.11.067

Reaction

Chain : A
UniProt : Q16539 (MK14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right PubMed:11010976, PubMed:35857590