Brand  (β version)

PDB ID: 3U88

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Ligands
Code Name Style Show Link
CHD Cholic acid PoSSuM
GGB L-canavanine PoSSuM
0BR (4beta,8alpha,9r)-6'-methoxy-10,11-dihydrocinchonan-9-ol PoSSuM
GLV Glyoxylic acid PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3U88   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of human menin in complex with MLL1 and LEDGF
Release Data : 2012-02-15
Compound :
mol_id molecule chains
1 Menin A,B
mol_id molecule chains synonym
2 Histone-lysine N-methyltransferase 2A M,N Lysine N-methyltransferase 2A,ALL-1,CXXC-type zinc finger protein 7,Myeloid/lymphoid or mixed-lineage leukemia,Myeloid/lymphoid or mixed-lineage leukemia protein 1,Trithorax-like protein,Zinc finger protein HRX
ec: 2.1.1.43
mol_id molecule chains synonym
3 Lens epithelium-derived growth factor C,D CLL-associated antigen KW-7,Dense fine speckles 70 kDa protein,DFS 70,Transcriptional coactivator p75/p52
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: MEN1, SCG2
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: KMT2A, ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: PSIP1, DFS70, LEDGF, PSIP2
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
Authors : Huang, J., Wan, B., Lei, M.
Keywords : menin, MEN1, MLL, JunD, LEDGF, TPR, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.

Huang, J.,Gurung, B.,Wan, B.  et al.
(2012)  Nature  482 : 542 - 546

PubMed: 22327296
DOI: 10.1038/nature10806

Reaction

Chain : A, B
UniProt : O00255 (MEN1_HUMAN)
Reaction : -
Chain : M, N
UniProt : Q03164 (KMT2A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine 2.1.1.364 PubMed:12453419, PubMed:19187761, PubMed:19556245, PubMed:24235145, PubMed:25561738, PubMed:26886794
left-to-right PubMed:19556245, PubMed:25561738
N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L- homocysteine - PubMed:19187761, PubMed:24235145, PubMed:25561738, PubMed:26886794
left-to-right PubMed:25561738
L-cysteinyl-[protein] + S-adenosyl-L-methionine = H(+) + S- adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein] - PubMed:24235145
left-to-right
Chain : C, D
UniProt : O75475 (PSIP1_HUMAN)
Reaction : -