Brand  (β version)

PDB ID: 3U5L

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Ligands
Code Name Style Show Link
08K 8-chloro-1,4-dimethyl-6-phenyl-4h-[1,2,4]triazolo[4,3-a][1,3,4]benzotriazepine PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 3U5L   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN/INHIBITOR
Title : Crystal Structure of the first bromodomain of human BRD4 in complex with a benzo-triazepine ligand (BzT-7)
Release Data : 2011-11-23
Compound :
mol_id molecule chains synonym
1 Bromodomain-containing protein 4 A Protein HUNK1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: BRD4, HUNK1
expression_system_strain: BL21(DE3)-R3
expression_system_vector_type: Plasmid
expression_system_plasmid: pNIC28-Bsa4
Authors : Filippakopoulos, P., Picaud, S., Felletar, I., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Bracher, F., Knapp, S., Structural Genomics Consortium (SGC)
Keywords : Bromodomain-containing protein 4 isoform long, BRD4, Bromodomain containing protein 4, CAP, HUNK1, MCAP, Mitotic chromosome associated protein, Structural Genomics Consortium, SGC, SIGNALING PROTEIN-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.3900 Å )
Citation :

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family.

Filippakopoulos, P.,Picaud, S.,Fedorov, O.  et al.
(2012)  Bioorg.Med.Chem.  20 : 1878 - 1886

PubMed: 22137933
DOI: 10.1016/j.bmc.2011.10.080

Reaction

Chain : A
UniProt : O60885 (BRD4_HUMAN)
Reaction : -