Het-PDB Navi2 (PDB: 3U15)

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Ligands
Code	Name		Style	Show	Link
03M	(5z)-5-[(6-chloro-7-methyl-1h-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione				PoSSuM
SO4	Sulfate ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3U15

Code :

3U15 PDBj RCSB PDB PDBe

Header :

PROTEIN BINDING

Title :

Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443

Release Data :

2012-06-27

Compound :

mol_id	molecule	chains	synonym
1	Protein Mdm4	A,B,C,D	Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4
	fragment: unp residues 14-111 mutation: C17S

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: MDM4, MDMX expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid

Authors :

Lukacs, C.M., Janson, C.A., Graves, B.J.

Keywords :

cell cycle, ubiquitin ligase, MDM2, MDMX, p53, PROTEIN BINDING

Exp. method :

X-RAY DIFFRACTION ( 1.80 Å )

Citation :

Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.

Graves, B.,Thompson, T.,Xia, M. et al.
(2012) Proc.Natl.Acad.Sci.USA 109 : 11788 - 11793

PDB ID: 3U15