Het-PDB Navi2 (PDB: 3TZM)

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Ligands
Code	Name		Style	Show	Link
085	4-[5-(1,3-benzodioxol-5-yl)-4-(pyridin-2-yl)-1h-imidazol-2-yl]benzamide				PoSSuM

Non-standard Residues
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Download interaction data: 3TZM

Code :

3TZM PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

TGF-beta Receptor type 1 in complex with SB431542

Release Data :

2012-05-23

Compound :

mol_id	molecule	chains	synonym
1	TGF-beta receptor type-1	A	TGFR-1, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, ALK-5, ALK5, Serine/threonine-protein kinase receptor R4, SKR4, TGF-beta type I receptor, Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TbetaR-I
	ec: 2.7.11.30 fragment: kinase domain, UNP residues 200-503

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: TGFBR1, ALK5, SKR4 expression_system_common: Fall armyworm expression_system_vector_type: plasmid expression_system_plasmid: pFastBAC

Authors :

Ogunjimi, A.A., Zeqiraj, E., Ceccarelli, D.F., Sicheri, F.

Keywords :

ALK5, SB431542, kinase domain, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.70 Å )

Citation :

Structural Basis for Specificity of TGFbeta Family Receptor Small Molecule Inhibitors

Ogunjimi, A.A.,Zeqiraj, E.,Ceccarelli, D.F. et al.
(2012) Cell Signal 24 : 476 - 483

Chain :

UniProt :

P36897 (TGFR1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein]	2.7.11.30	-
	-	-
ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein]	2.7.11.30	-
	-	-

PDB ID: 3TZM