Brand  (β version)

PDB ID: 3TZB

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
AA 9-aminoacridine PoSSuM
Non-standard Residues
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Structure summary

Code : 3TZB   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Quinone Oxidoreductase (NQ02) bound to NSC13000
Release Data : 2011-11-02
Compound :
mol_id molecule chains synonym
1 Ribosyldihydronicotinamide dehydrogenase [quinone] A,B,C,D NRH dehydrogenase [quinone] 2, NRH:quinone oxidoreductase 2, Quinone reductase 2, QR2
ec: 1.10.99.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: NQO2, NMOR2
Authors : Dunstan, M.S., Leys, D.
Keywords : Oxidoreductase, FAD
Exp. method : X-RAY DIFFRACTION ( 2.1901 Å )
Citation :

In silico screening reveals structurally diverse, nanomolar inhibitors of NQO2 that are functionally active in cells and can modulate NF-kappa B signaling.

Nolan, K.A.,Dunstan, M.S.,Caraher, M.C.  et al.
(2012)  Mol.Cancer Ther.  11 : 194 - 203

PubMed: 22090421
DOI: 10.1158/1535-7163.MCT-11-0543

Reaction

Chain : A, B, C, D
UniProt : P16083 (NQO2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside 1.10.5.1 PubMed:18579530
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