Brand  (β version)

PDB ID: 3TXO

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Ligands
Code Name Style Show Link
07U 2-methyl-N~1~-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine PoSSuM
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Structure summary

Code : 3TXO   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : PKC eta kinase in complex with a naphthyridine
Release Data : 2011-11-30
Compound :
mol_id molecule chains synonym
1 Protein kinase C eta type A PKC-L, nPKC-eta
ec: 2.7.11.13
fragment: kinase domain, residues 333-683
mutation: E675S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PRKCH, PKCL, PRKCL
expression_system_common: Fall armyworm
Authors : Stark, W., Rummel, G., Cowan-Jacob, S.W.
Keywords : kinase, phosphotransferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.05 Å )
Citation :

2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes.

van Eis, M.J.,Evenou, J.P.,Floersheim, P.  et al.
(2011)  Bioorg.Med.Chem.Lett.  21 : 7367 - 7372

PubMed: 22078216
DOI: 10.1016/j.bmcl.2011.10.025

Reaction

Chain : A
UniProt : P24723 (KPCL_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.13 PubMed:34593629
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.13 PubMed:34593629
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