Brand  (β version)

PDB ID: 3TV7

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Ligands
Code Name Style Show Link
07Q 1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 3TV7   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Human Rho-associated protein kinase 1 (ROCK 1) in COMPLEX WITH RKI1342
Release Data : 2012-02-15
Compound :
mol_id molecule chains synonym
1 Rho-associated protein kinase 1 A,B,C,D Renal carcinoma antigen NY-REN-35, Rho-associated, coiled-coil-containing protein kinase 1, p160 ROCK-1, p160ROCK
ec: 2.7.11.1
fragment: N-terminal kinase domain, residue 6-415
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: ROCK1
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: pFB-Dual-PBL
Authors : Martin, M.P., Zhu, J.-Y., Schonbrunn, E.
Keywords : kinase, dimer, dimerization, myosin, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.750 Å )
Citation :

Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).

Pireddu, R.,Forinash, K.D.,Sun, N.N.  et al.
(2012)  Medchemcomm  3 : 699 - 709

PubMed: 23275831
DOI: 10.1039/C2MD00320A

Reaction

Chain : A, B, C, D
UniProt : Q13464 (ROCK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:23093407, PubMed:23355470
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:23093407, PubMed:23355470
left-to-right PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:23093407, PubMed:23355470