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Ligands
Code Name Style Show Link
FPW 1-benzyl-N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-2-oxo-1,2-dihydropyridine-3-carboxamide
Non-standard Residues
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Glycosylation
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Code : 3TUC   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of SYK kinase domain with 1-benzyl-N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Release Data : 2012-08-29
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase SYK A Spleen tyrosine kinase
ec: 2.7.10.2
fragment: Spleen Tyrosine Kinase
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
gene: SYK
expression_system_vector_type: Baculovirus
Authors : Lovering, F., McDonald, J., Whitlock, G., Glossop, P., Phillips, C., Sabnis, Y., Ryan, M., Fitz, L., Lee, J., Chang, J.S., Han, S., Kurumbail, R., Thorarenson, A.
Keywords : kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Identification of Type-II Inhibitors Using Kinase Structures.

Lovering, F.,McDonald, J.,Whitlock, G.A.  et al.
(2012)  Chem.Biol.Drug Des.  80 : 657 - 664

PubMed: 22759374
DOI: 10.1111/j.1747-0285.2012.01443.x

Chain : A
UniProt : P43405 (KSYK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:33782605, PubMed:34634301
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