Het-PDB Navi2 (PDB: 3TU1)

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Ligands
Code	Name		Style	Show	Link
07G	2-(tert-butylamino)-1-(2-carboxy-6-chloro-1h-indol-3-yl)-1-[(3,4-difluorobenzyl)(formyl)amino]-2-oxoethylium				PoSSuM

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Download interaction data: 3TU1

Code :

3TU1 PDBj RCSB PDB PDBe

Header :

LIGASE

Title :

Exhaustive Fluorine Scanning towards Potent p53-MDM2 Antagonist

Release Data :

2011-11-02

Compound :

mol_id	molecule	chains	synonym
1	E3 ubiquitin-protein ligase Mdm2	A	Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2
	ec: 6.3.2.- fragment: p53 binding domain (UNP Residues 18-105)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: MDM2

Authors :

Wolf, S., Huang, Y., Koes, D., Popowicz, G.M., Camacho, C.J., Holak, T.A., Doemling, A.

Keywords :

p53-binding protein Mdm2, Oncoprotein Mdm2, Double minute 2 protein, Hdm2, oncoprotein, p53, nucleus, ligase

Exp. method :

X-RAY DIFFRACTION ( 1.603 Å )

Citation :

Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists.

Huang, Y.,Wolf, S.,Koes, D. et al.
(2012) Chemmedchem 7 : 49 - 52

Chain :

UniProt :

Q00987 (MDM2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.	2.3.2.27	PubMed:12821780
	-	PubMed:12821780

PDB ID: 3TU1