Het-PDB Navi2 (PDB: 3TTJ)

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Ligands
Code	Name		Style	Show	Link
JBI	9-cyclopentyl-N~8~-(2-fluorophenyl)-N~2~-(4-methoxyphenyl)-9h-purine-2,8-diamine				PoSSuM

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Download interaction data: 3TTJ

Code :

3TTJ PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal Structure of JNK3 complexed with CC-359, a JNK inhibitor for the prevention of ischemia-reperfusion injury

Release Data :

2012-01-25

Compound :

mol_id	molecule	chains	synonym
1	Mitogen-activated protein kinase 10	A	MAP kinase 10, MAPK 10, MAP kinase p49 3F12, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3
	ec: 2.7.11.24

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: MAPK10, JNK3, JNK3A, PRKM10 expression_system_strain: BL21 (DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET21d

Authors :

Plantevin-Krenitsky, V., Delgado, M., Nadolny, L., Sahasrabudhe, K., Ayala, S., Clareen, S., Hilgraf, R., Albers, R., Kois, A., Hughes, K., Wright, J., Nowakowski, J., Sudbeck, E., Ghosh, S., Bahmanyar, S., Chamberlain, P., Muir, J., Cathers, B.E., Giegel, D., Xu, L., Celeridad, M., Moghaddam, M., Khatsenko, O., Omholt, P., Katz, J., Pai, S., Fan, R., Tang, Y., Shirley, M.A., Benish, B., Blease, K., Raymon, H., Bhagwat, S., Bennett, B., Satoh, Y.

Keywords :

Mitogen-Activated Protein Kinase 10, jnk3, Protein Kinase Inhibitors, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury.

Krenitsky, V.P.,Delgado, M.,Nadolny, L. et al.
(2012) Bioorg.Med.Chem.Lett. 22 : 1427 - 1432

PubMed: 22226655
DOI: 10.1016/j.bmcl.2011.12.028

PDB ID: 3TTJ

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