PDB ID: 3TL5
Hetero Atom Contents
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980 | (2s)-1-(4-{[2-(2-aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-D]pyrimidin-6-yl]methyl}piperazin-1-yl)-2-hydroxypropan-1-one | PoSSuM |
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Download interaction data: 3TL5
Structure summary
Code : | 3TL5 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||
Title : | Discovery of GDC-0980: a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor for the Treatment of Cancer | ||||||||||||
Release Data : | 2011-11-02 | ||||||||||||
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Authors : | Murray, J.M., Wiesmann, C. | ||||||||||||
Keywords : | TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.788 Å ) | ||||||||||||
Citation : |
Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer.
Sutherlin, D.P.,Bao, L.,Berry, M.
et al.
PubMed: 21981714 |
Reaction
Chain : | A | |||||||||||||||||||||||
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UniProt : | P48736 (PK3CG_HUMAN) | |||||||||||||||||||||||
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