Het-PDB Navi2 (PDB: 3TGG)

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Ligands
Code	Name	Link
0H3	7-(6-methoxypyridin-3-yl)-4-{[2-(propan-2-yloxy)ethyl]amino}-1-(2-propoxyethyl)pyrido[4,3-D]pyrimidin-2(1h)-one	PoSSuM
MG	Magnesium ion	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
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Download interaction data: 3TGG

Code :

3TGG PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

A novel series of potent and selective PDE5 inhibitor2

Release Data :

2012-01-25

Compound :

mol_id	molecule	chains	synonym
1	cGMP-specific 3',5'-cyclic phosphodiesterase	A	cGMP-binding cGMP-specific phosphodiesterase, CGB-PDE
	ec: 3.1.4.35 fragment: Catalytic residues 534-858 mutation: R658P, N662Q, S663F, Y664L, Q666T, R667N, Q674L, L675M, C677D, H678E, I680V, M681L, Q751E

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	SPODOPTERA FRUGIPERDA (taxid:7108)
	gene: PDE5A, PDE5 expression_system_common: FALL ARMYWORM expression_system_vector_type: Baculovirus

Authors :

Han, S.

Keywords :

phosphodiesterase, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.91 Å )

Citation :

Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region.

Hughes, R.O.,Maddux, T.,Joseph Rogier, D. et al.
(2011) Bioorg.Med.Chem.Lett. 21 : 6348 - 6352

Chain :

UniProt :

O76074 (PDE5A_HUMAN)

PDB ID: 3TGG