Het-PDB Navi2 (PDB: 3TDC)

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Ligands
Code	Name		Style	Show	Link
0EU	1-[3-({4-[(5s)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl}carbonyl)-1-benzothiophen-2-yl]-3-ethylurea				PoSSuM

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Glycosylation
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Download interaction data: 3TDC

Code :

3TDC PDBj RCSB PDB PDBe

Header :

LIGASE/LIGASE INHIBITOR

Title :

Crystal Structure of Human Acetyl-CoA carboxylase 2

Release Data :

2011-10-12

Compound :

mol_id	molecule	chains
1	Acetyl-CoA carboxylase 2 variant	A
	ec: 6.4.1.2 fragment: UNP residues 921-1676

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	expression_system_common: Fall armyworm expression_system_vector_type: Baculovirus

Authors :

Dougan, D.R., Mol, C.D.

Keywords :

biotin, malonyl-CoA, carboxylase, LIGASE-LIGASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.41 Å )

Citation :

Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.

Yamashita, T.,Kamata, M.,Endo, S. et al.
(2011) Bioorg.Med.Chem.Lett. 21 : 6314 - 6318

Chain :

UniProt :

Q59GJ9 (Q59GJ9_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl- CoA + phosphate	6.4.1.2	ARBA:ARBA00001448
	left-to-right	ARBA:ARBA00001448

PDB ID: 3TDC