Brand  (β version)

PDB ID: 3TCP

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Ligands
Code Name Style Show Link
CKJ 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1h-pyrazolo[3,4-D]pyrimidin-6-amine PoSSuM
CL Chloride ion PoSSuM
CA Calcium ion PoSSuM
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Structure summary

Code : 3TCP   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC569
Release Data : 2012-06-20
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase Mer A,B Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK
ec: 2.7.10.1
fragment: catalytic domain, UNP residues 570-864
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: MERTK, MER
expression_system_strain: Rosetta BL21(DE3)pLysS
expression_system_vector_type: plasmid
expression_system_plasmid: pET28
Authors : Liu, J., Yang, C., Simpson, C., DeRyckere, D., Van Deusen, A., Miley, M., Kireev, D.B., Norris-Drouin, J., Sather, S., Hunter, D., Patel, H.S., Janzen, W.P., Machius, M., Johnson, G., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
Keywords : tyrosine kinase, acute lymphoblastic leukemia, rational structure-based drug design, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.69 Å )
Citation :

Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.

Liu, J.,Yang, C.,Simpson, C.  et al.
(2012)  ACS Med Chem Lett  3 : 129 - 134

PubMed: 22662287

Reaction

Chain : A, B
UniProt : Q12866 (MERTK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028
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