Het-PDB Navi2 (PDB: 3TAG)

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Ligands
Code	Name		Style	Show	Link
SO4	Sulfate ion				PoSSuM

Non-standard Residues
Code	Name	Show
C37	5-fluoro-2'-deoxy-cytidine-5'-monophosphate

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 3TAG

Code :

3TAG PDBj RCSB PDB PDBe

Header :

Transferase/DNA

Title :

5-fluorocytosine paired with dAMP in RB69 gp43

Release Data :

2011-11-09

Compound :

mol_id	molecule	chains	synonym
1	DNA-directed DNA polymerase	A,B,C,D	Gp43
	ec: 2.7.7.7,3.1.11.- mutation: D222A, D327A

mol_id	molecule	chains
2	DNA (5'-D(CPCP(C37)PGPGPTPAPTPGPAPCPAPGPCPCPGPCPG)-3')	E,I,G,K
	other_details: Template DNA

mol_id	molecule	chains
3	DNA (5'-D(GPCPGPGPCPTPGPTPCPAPTPAPCPCP*A)-3')	F,J,H,L
	other_details: Primer DNA

Source :

mol_id	organism_scientific	expression_system
1	Escherichia phage RB69 (taxid:12353)	Escherichia coli (taxid:562)
	gene: 43

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes

mol_id	organism_scientific
3	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Zahn, K.E.

Keywords :

Transferase-DNA complex

Exp. method :

X-RAY DIFFRACTION ( 2.95 Å )

Citation :

The miscoding potential of 5-hydroxycytosine arises due to template instability in the replicative polymerase active site.

Zahn, K.E.,Averill, A.,Wallace, S.S. et al.
(2011) Biochemistry 50 : 10350 - 10358

PubMed: 22026756
DOI: 10.1021/bi201219s

Chain :

A, B, C, D

UniProt :

Q38087 (DPOL_BPR69)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate	2.7.7.7	HAMAP-Rule:MF_04100, PubMed:17098747, PubMed:18503083, PubMed:20795733, PubMed:22616982, PubMed:24116139
	-
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000255 \| HAMAP-Rule:MF_04100 ECO:0000269 \| PubMed:20166752 ECO:0000269 \| PubMed:22026756 ECO:0000305 \| PubMed:11389835 ECO:0000305 \| PubMed:15057282 ECO:0000305 \| PubMed:15057283 ECO:0000305 \| PubMed:17718515 ECO:0000305 \| PubMed:18503083 ECO:0000305 \| PubMed:20166748 ECO:0000305 \| PubMed:21158418 ECO:0000305 \| PubMed:21566148 ECO:0000305 \| PubMed:21923197 ECO:0000305 \| PubMed:22571765 ECO:0000305 \| PubMed:23214497 ECO:0000305 \| PubMed:23921641 ECO:0000305 \| PubMed:24116139	-

PDB ID: 3TAG

Hetero Atom Contents

Structure summary

Reaction