Brand  (β version)

PDB ID: 3T3R

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
HEM Protoporphyrin ix containing Fe PoSSuM
9PL (3s,4r)-3-ethyl-4-[(1-methyl-1h-imidazol-5-yl)methyl]dihydrofuran-2(3h)-one PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3T3R   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Human Cytochrome P450 2A6 in complex with Pilocarpine
Release Data : 2011-12-07
Compound :
mol_id molecule chains synonym
1 Cytochrome P450 2A6 A,B,C,D CYPIIA6, Coumarin 7-hydroxylase, Cytochrome P450 IIA3, Cytochrome P450(I)
ec: 1.14.14.1
fragment: unp residues 29-494
mutation: Y392F
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CYP2A3, CYP2A6
expression_system_strain: TOPP3
expression_system_vector_type: plasmid
expression_system_plasmid: pKK2A6dH
Authors : DeVore, N.M., Scott, E.E.
Keywords : CYP2A6, cytochrome P450 2A6, P450 2A6, heme protein, monooxygenase, drug metabolism, xenobiotic metabolism, endoplasmic reticulum, membrane, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine.

DeVore, N.M.,Meneely, K.M.,Bart, A.G.  et al.
(2012)  Febs J.  279 : 1621 - 1631

PubMed: 22051186
DOI: 10.1111/j.1742-4658.2011.08412.x

Reaction

Chain : A, B, C, D
UniProt : P11509 (CP2A6_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2- exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] - PubMed:11695850
-