Brand  (β version)

PDB ID: 3T07

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Ligands
Code Name Style Show Link
09C (3s,5r)-3,5-bis(6-bromo-1h-indol-3-yl)piperazin-2-one PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3T07   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of S. aureus Pyruvate Kinase in complex with a naturally occurring bis-indole alkaloid
Release Data : 2011-10-26
Compound :
mol_id molecule chains synonym
1 Pyruvate kinase A,B,C,D PK
ec: 2.7.1.40
Source :
mol_id organism_scientific expression_system
1 Staphylococcus aureus subsp. aureus  (taxid:282458) Escherichia coli  (taxid:469008)
strain: MRSA252
gene: pyk, SAR1776
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a
Authors : Worrall, L.J., Vuckovic, M., Strynadka, N.C.J.
Keywords : tetramer, ligand, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 3.300 Å )
Citation :

Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.

Zoraghi, R.,Worrall, L.,See, R.H.  et al.
(2011)  J.Biol.Chem.  286 : 44716 - 44725

PubMed: 22030393
DOI: 10.1074/jbc.M111.289033

Reaction

Chain : A, B, C, D
UniProt : Q6GG09 (KPYK_STAAR)
Reaction: EC: Evidence:
Physiological Direction:
ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate 2.7.1.40 -
-