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Ligands
Code Name Style Show Link
CA Calcium ion
CL Chloride ion
JRG N~2~-{[(1s)-1-carboxy-3-(methylsulfanyl)propyl]carbamoyl}-N~6~-(4-iodobenzoyl)-L-lysine
ZN Zinc ion
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show
Code : 3SJF   PDBj   RCSB PDB   PDBe
Header : Hydrolase/hydrolase inhibitor
Title : X-ray structure of human glutamate carboxypeptidase II in complex with a urea-based inhibitor (A25)
Release Data : 2011-10-05
Compound :
mol_id molecule chains synonym
1 Glutamate carboxypeptidase 2 A Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Prostate-specific membrane antigen, PSM, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase
ec: 3.4.17.21
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Drosophila melanogaster  (taxid:7227)
gene: FOLH1, FOLH, NAALAD1, PSM, PSMA, GIG27
expression_system_cell_line: Schneider's S2 cells
Authors : Plechanovova, A., Byun, Y., Alquicer, G., Skultetyova, L., Mlcochova, P., Nemcova, A., Kim, H., Navratil, M., Mease, R., Lubkowski, J., Pomper, M., Konvalinka, J., Rulisek, L., Barinka, C.
Keywords : hydrolase, metallopeptidase, Hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.65 Å )
Citation :

Novel Substrate-Based Inhibitors of Human Glutamate Carboxypeptidase II with Enhanced Lipophilicity.

Plechanovova, A.,Byun, Y.,Alquicer, G.  et al.
(2011)  J.Med.Chem.  54 : 7535 - 7546

PubMed: 21923190
DOI: 10.1021/jm200807m

Chain : A
UniProt : Q04609 (FOLH1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates. 3.4.17.21 -
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