Het-PDB Navi2 (PDB: 3SGX)

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Ligands
Code	Name		Style	Show	Link
0FW	4-{3-[(biphenyl-4-ylcarbonyl)amino]phenoxy}benzene-1,2-dicarboxylic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3SGX

Code :

3SGX PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE Inhibitor

Title :

Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1100

Release Data :

2012-12-19

Compound :

mol_id	molecule	chains	synonym
1	Undecaprenyl pyrophosphate synthase	A,B	UPP synthase, Di-trans,poly-cis-decaprenylcistransferase, Undecaprenyl diphosphate synthase, UDS
	ec: 2.5.1.31

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:83333)	Escherichia coli (taxid:562)
	strain: K12 gene: b0174, ispU, JW0169, rth, uppS, yaeS expression_system_vector_type: plasmid expression_system_plasmid: pET32

Authors :

Cao, R., Liu, Y.-L., Oldfield, E.

Keywords :

Alpha/beta, TRANSFERASE, TRANSFERASE-TRANSFERASE Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.4500 Å )

Citation :

Antibacterial drug leads targeting isoprenoid biosynthesis.

Zhu, W.,Zhang, Y.,Sinko, W. et al.
(2013) Proc.Natl.Acad.Sci.USA 110 : 123 - 128

Chain :

A, B

UniProt :

P60472 (UPPS_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di- trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate	2.5.1.31	-
	-	-

PDB ID: 3SGX