Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
ZN Zinc ion
03T 1-benzothiophene-2-sulfonamide
Code : 3S74
Header : LYASE
Title : The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
Release Data : 2011-10-19
Compound :
mol_id molecule chains synonym
1 Carbonic anhydrase 2 B Carbonate dehydratase II, Carbonic anhydrase C, CAC, Carbonic anhydrase II, CA-II
ec: 4.2.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: CA2
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
Authors : Snyder, P.W., Heroux, A., Whitesides, G.W.
Keywords : alpha beta, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.4000 Å )
Citation :

Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase.

Snyder, P.W.,Mecinovic, J.,Moustakas, D.T.  et al.
(2011)  Proc.Natl.Acad.Sci.USA  108 : 17889 - 17894

PubMed: 22011572
DOI: 10.1073/pnas.1114107108

Chain : B
UniProt : P00918 (CAH2_HUMAN)
Reaction : H(2)CO(3) = CO(2) + H(2)O.