Brand  (β version)

PDB ID: 3S3J

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
02Y 6-diazonio-5-oxo-L-norleucine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
PHQ Benzyl chlorocarbonate

Structure summary

Code : 3S3J   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Transglutaminase 2 in complex with a novel inhibitor
Release Data : 2012-06-06
Compound :
mol_id molecule chains synonym
1 Protein-glutamine gamma-glutamyltransferase 2 A Tissue transglutaminase, Transglutaminase C, TG(C), TGC, TGase C, Transglutaminase H, TGase H, Transglutaminase-2, TGase-2
ec: 2.3.2.13
fragment: unp residues 2-687
mol_id molecule chains
2 Peptide inhibitor B
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TGM2
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Lindemann, I., Heine, A., Klebe, G.
Keywords : Transglutaminase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

Inhibitors of Transglutaminase 2: A therapeutic option in celiac disease

Lindemann, I.,Boettcher, J.,Oertel, K.  et al.
To be Published 

Reaction

Chain : A
UniProt : P21980 (TGM2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L- lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+) 2.3.2.13 PROSITE-ProRule:PRU10024, PubMed:23941696, PubMed:24349085, PubMed:31991788
left-to-right PubMed:23941696, PubMed:24349085, PubMed:31991788
L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl- [protein] + NH4(+) - PubMed:30867594
left-to-right
L-glutaminyl-[protein] + dopamine = 5-dopaminyl-L-glutamyl- [protein] + NH4(+) - PubMed:32273471
left-to-right
L-glutaminyl-[protein] + histamine = 5-histaminyl-L-glutamyl- [protein] + NH4(+) - PubMed:23797785
left-to-right
L-glutaminyl-[protein] + (R)-noradrenaline = 5-(R)- noradrenalinyl-L-glutamyl-[protein] + NH4(+) - UniProtKB:P08587
left-to-right
L-glutaminyl-[protein] + H2O = L-glutamyl-[protein] + NH4(+) 3.5.1.44 PubMed:20547769, PubMed:9623982
left-to-right
Cofactor: Evidence: Note:
Ca(2+) ECO:0000269 | PubMed:31991788
ECO:0000305 | PubMed:18092889
-