PDB ID: 3RO9
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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NDP | Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate | PoSSuM | |||
06U | 6-ethyl-5-{(3r)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine | PoSSuM |
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Download interaction data: 3RO9
Structure summary
Code : | 3RO9 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR | ||||||||||||
Title : | Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006) | ||||||||||||
Release Data : | 2012-05-09 | ||||||||||||
Compound : |
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Source : |
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Authors : | Paulsen, J.L., Anderson, A.C. | ||||||||||||
Keywords : | Antifungal Agents, Candida glabrata, Drug Design, Enzyme Inhibitors, Fungal Proteins, Models, Molecular Structure, Structure-Activity Relationship, Tetrahydrofolate Dehydrogenase, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.5960 Å ) | ||||||||||||
Citation : |
Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.
Paulsen, J.L.,Viswanathan, K.,Wright, D.L.
et al.
PubMed: 23375226 |
Reaction
Chain : | A, B |
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UniProt : | Q6FPH0 (Q6FPH0_CANGA) |
Reaction : | - |