Het-PDB Navi2 (PDB: 3RM8)

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Ligands
Code	Name		Style	Show	Link
RM8	2-methyl-3-{[4-(pyridin-2-yl)piperazin-1-yl]methyl}-1h-indole				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3RM8

Code :

3RM8 PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

AMCase in complex with Compound 2

Release Data :

2011-08-24

Compound :

mol_id	molecule	chains	synonym
1	Acidic mammalian chitinase	A,B	AMCase, Lung-specific protein TSA1902
	ec: 3.2.1.14 fragment: catalytic domain residues 22-408

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	CRICETULUS GRISEUS (taxid:10029)
	gene: CHIA expression_system_common: CHINESE HAMSTER expression_system_cell_line: OVARY

Authors :

Olland, A.

Keywords :

HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.80 Å )

Citation :

Identification and Characterization of Acidic Mammalian Chitinase Inhibitors

Cole, D.C.,Olland, A.M.,Jacob, J. et al.
(2010) J.Med.Chem. 53 : 6122 - 6128

Chain :

A, B

UniProt :

Q9BZP6 (CHIA_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.	3.2.1.14	PubMed:18824549, PubMed:19241384, PubMed:19435888
	-	PubMed:18824549, PubMed:19241384, PubMed:19435888

PDB ID: 3RM8