Brand  (β version)

PDB ID: 3RK7

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Ligands
Code Name Style Show Link
08Z 4-{[4-amino-5-(pyridin-3-ylcarbonyl)-1,3-thiazol-2-yl]amino}benzamide PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 3RK7   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : CDK2 in complex with inhibitor RC-2-71
Release Data : 2012-10-31
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 2 A CDK2, Cell division protein kinase 2, p33 protein kinase
ec: 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CDK2
expression_system_strain: TUNER(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pGEX6P-1
Authors : Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Keywords : protein kinase, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.

Schonbrunn, E.,Betzi, S.,Alam, R.  et al.
(2013)  J.Med.Chem.  56 : 3768 - 3782

PubMed: 23600925
DOI: 10.1021/jm301234k

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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