Brand  (β version)

PDB ID: 3R75

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Ligands
Code Name Style Show Link
BEZ Benzoic acid PoSSuM
MG Magnesium ion PoSSuM
PO4 Phosphate ion PoSSuM
PYR Pyruvic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
CYG 2-amino-4-(amino-3-oxo-propylsulfanylcarbonyl)-butyric acid
Glycosylation
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Structure summary

Code : 3R75   PDBj   RCSB PDB   PDBe
Header : LYASE, BIOSYNTHETIC PROTEIN
Title : Crystal structure of 2-amino-2-desoxyisochorismate synthase (ADIC) synthase PhzE from Burkholderia lata 383 in complex with benzoate, pyruvate, glutamine and contaminating Zn2+
Release Data : 2011-03-30
Compound :
mol_id molecule chains
1 Anthranilate/para-aminobenzoate synthases component I A,B
ec: 4.1.3.27
Source :
mol_id organism_scientific expression_system
1 Burkholderia sp.  (taxid:269483) Escherichia coli  (taxid:469008)
strain: 383
gene: Bcep18194_B1570
expression_system_strain: Rosetta 2 pLysS
expression_system_vector_type: plasmid
expression_system_plasmid: pET19modTEV
Authors : Li, Q.A., Mavrodi, D.V., Thomashow, L.S., Roessle, M., Blankenfeldt, W.
Keywords : ammonia channel, chorismate, type 1 glutamine amidotransferase, phenazine biosynthesis, LYASE, synthase, BIOSYNTHETIC PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.1000 Å )
Citation :

Ligand Binding Induces an Ammonia Channel in 2-Amino-2-desoxyisochorismate (ADIC) Synthase PhzE.

Li, Q.A.,Mavrodi, D.V.,Thomashow, L.S.  et al.
(2011)  J.Biol.Chem.  286 : 18213 - 18221

PubMed: 21454481
DOI: 10.1074/jbc.M110.183418

Reaction

Chain : A, B
UniProt : Q396C7 (Q396C7_BURL3)
Reaction: EC: Evidence:
Physiological Direction:
chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate 4.1.3.27 ARBA:ARBA00000329
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