Brand  (β version)

PDB ID: 3R54

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Ligands
Code Name Style Show Link
FP6 Pyrrolidine-1-carbaldehyde PoSSuM
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Structure summary

Code : 3R54   PDBj   RCSB PDB   PDBe
Header : ISOMERASE/ISOMERASE INHIBITOR
Title : Human Cyclophilin D Complexed with a Fragment
Release Data : 2012-03-21
Compound :
mol_id molecule chains synonym
1 Peptidyl-prolyl cis-trans isomerase F, mitochondrial A Cyclophilin F, PPIase F, Rotamase F
ec: 5.2.1.8
fragment: UNP residues 43-207
mutation: K175I
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PPIF, CYP3
Authors : Colliandre, L., Ahmed-Belkacem, H., Bessin, Y., Pawlotsky, J.M., Guichou, J.F.
Keywords : beta barrel, prolyl cis/trans isomerase, mitochondria, inhibitor, ISOMERASE-ISOMERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.35 Å )
Citation :

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.

Ahmed-Belkacem, A.,Colliandre, L.,Ahnou, N.  et al.
(2016)  Nat Commun  7 : 12777 - 12777

PubMed: 27652979
DOI: 10.1038/ncomms12777

Reaction

Chain : A
UniProt : P30405 (PPIF_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0) 5.2.1.8 PubMed:20676357
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